米托金 (MitoQ) 补充剂对有氧运动性能和氧化损伤的影响:系统性审查和元分析
Oliver Gonzalo-Skok1, Rafael A Casuso2
1Department of Communication and Education, Faculty of Physical Activity and Sports, Universidad Loyola Andalucía, Sevilla, Spain.
Sports medicine - open
|July 9, 2024
概括
米托金 (MitoQ) 有效地减少了运动引起的氧化损伤,但没有改善耐力表现. 然而,MitoQ可能会提高周围动脉疾病 (PAD) 患者的运动耐受性.
科学领域:
- 运动生理学 运动生理学
- 线粒体生物化学 线粒体生物化学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 骨肌肉的收缩产生了来自线粒体和细胞源的活性氧物种 (ROS).
- 非特异性抗氧化剂产生不一致的运动性能益处.
- 针对线粒体的抗氧化剂米托金 (MitoQ) 正在研究其对运动反应的影响.
研究的目的:
- 对MitoQ对有氧耐力和运动诱导的氧化损伤的影响的研究进行定量合成.
- 评估MitoQ补充剂在运动员和活跃人群中的疗效.
- 为了确定MitoQ在特定的患者群体体体验运动限制的潜在益处.
主要方法:
- 一项比较MitoQ补充剂与安慰剂的研究的元分析.
- 在PubMed,Web of Science和SCOPUS数据库中进行的搜索截至2024年1月16日.
- 纳入标准规定了MitoQ与安慰剂,急性炼反应,以及交叉设计的充足的洗期.
主要成果:
- 分析了8项涉及188名参与者的研究.
- MitoQ显著降低了运动诱导的氧化损伤 (SMD: -1.33).
- MitoQ没有改善耐力运动的表现 (SMD: -0.50);然而,它可能有利于患有外周动脉疾病 (PAD) 的个人.
结论:
- MitoQ有效地减轻了运动引起的氧化损伤.
- 目前的证据不支持MitoQ补充剂提高有氧运动性能.
- 急性MitoQ补充剂显示了改善PAD患者的运动耐受性的潜力,这需要进一步研究长期影响和最佳剂量.
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