在没有狼视网膜病变的幼年系统性红斑狼中分析视网膜亚层
1Department of Ophthalmology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Clinical rheumatology
|July 9, 2024
概括
青少年系统性红斑狼 (JSLE) 与视网膜稀薄有关,特别是在视网膜内层,即使没有视网膜病变. 这种稀释与红细胞沉积率 (ESR) 相对应.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 青少年系统性红斑狼 (JSLE) 可以影响包括眼睛在内的各种器官.
- 在没有视网膜病变的JSLE患者中评估眼部变化对于早期检测和管理至关重要.
研究的目的:
- 在没有视网膜病变的JSLE患者中,分析视网膜亚层和周视网膜神经纤维层 (pRNFL) 厚度.
- 调查视网膜厚度与ESR和疾病持续时间等疾病活动标志物之间的相关性.
主要方法:
- 用光学连贯断层扫描 (OCT) 对36名JSLE患者和30名对照者的回顾性分析.
- 测量各种视网膜层厚度,包括状细胞层 (GCL),内状层 (IPL) 和外核层 (ONL).
主要成果:
- 与对照组相比,JSLE患者表现出较薄的视网膜部门 (I3,T3) 和降低的GLC厚度 (I3,S6).
- 在JSLE组中观察到IPL (S6) 和ONL (中央部门) 厚度减少.
- 在I3和T3部门的视网膜稀释与红细胞沉积率 (ESR) 有负相关性.
结论:
- 视网膜变薄,特别是在视网膜内层,在没有被诊断为视网膜病变的JSLE患者中也存在.
- 观察到的视网膜变化与疾病活性有关,正如与ESR的相关性所示.
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