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Updated: Jun 21, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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在LAG3中,启动密码子变异与LAG-3表达量的降低和自身免疫性甲状腺疾病风险的增加有关

Saedis Saevarsdottir1,2,3, Kristbjörg Bjarnadottir4, Thorsteinn Markusson4,5

  • 1deCODE genetics/Amgen, Inc., Reykjavik, Iceland. saedis.saevarsdottir@decode.is.

Nature communications
|July 9, 2024
PubMed
概括

一项大型遗传研究发现了290种与自身免疫性甲状腺疾病 (AITD) 相关的变异. 一种罕见的LAG3基因变异通过改变免疫检查点蛋白质表达,显著增加了AITD风险.

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