中间前额叶皮质从前额叶到带状皮质的长距离抑制增强了网络活动和响应执行
Nao Utashiro1, Duncan Archibald Allan MacLaren1, Yu-Chao Liu1
1Department of Clinical Neurobiology at the Medical Faculty of the Heidelberg University and of the German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nature communications
|July 9, 2024
概括
研究人员探索了大脑区域如何沟通以控制行为. 他们发现,中间前额叶皮层区域之间的特定GABAergic投影调节神经活动,并影响小鼠的冲动性和疼痛反应.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 细胞神经科学 细胞神经科学
背景情况:
- 中间前额叶皮层 (mPFC) 对于自上而下的行为控制至关重要.
- 了解mPFC分区域之间的交叉通话对于阐明这种控制至关重要.
- 在mPFC中特定的GABAergic投射的作用仍然在很大程度上是未知的.
研究的目的:
- 在mPFC中,研究前皮区域 (PrL) 与带状皮区域1和2 (Cg1/2) 之间的功能连接.
- 为了确定参与这个mPFC交叉对话的特定神经元群体.
- 确定这种沟通通路如何影响神经活动和行为.
主要方法:
- 在雄性小鼠中病毒介导的神经追踪.
- 在体外电生理学.
- 在体内摄取的成像.
- 对冲动性和机械反应性的行为测试.
主要成果:
- 确定了两种类型的1层GABAergic内部神经元,单花束细胞 (SBC) 和神经状细胞 (NGF),介导PrL到Cg1/2投影.
- 证明了这些GABAergic投射可以消毒Cg1/2.2.中的第5层输出神经元.
- 显示,激活这些投影调节冲动性和机械反应性.
结论:
- 在mPFC区域 (PrL到Cg1/2) 之间的特定GABAergic投射是上下控制的关键.
- 这一途径涉及SBC和NGF,将投影神经元与皮层电路连接起来.
- 已识别的电路在通过输出神经元的消抑制来调节行为方面发挥着重要作用.
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