背景不变的信念得到了男性的前额叶皮层中单个单元功能连接的动态重新配置的支持
Jean-Paul Noel1,2, Edoardo Balzani3,4, Cristina Savin3
1Center for Neural Science, New York University, New York City, NY, USA. Jpn5@nyu.edu.
Nature communications
|July 9, 2024
概括
前额叶皮层的神经回路在自然行为过程中保持稳定的信念. 这些电路中的动态功能连接支持灵活的决策,即使感官信息有限.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 自然行为依赖于动态的信念,而不仅仅是即时的感官输入.
- 灵活,不变背景的信念的神经基础仍然不太了解.
- 了解大脑如何将感官信息与内部模型集成,对于解释现实世界的认知至关重要.
研究的目的:
- 为了调查灵长类动物大脑中的神经回路如何在自然主义行为过程中实例化灵活,不变背景的信念.
- 探索动态功能连接在维持稳定的人口代码中的作用,尽管有不同的感官证据.
- 确定参与更新和维护任务相关信念的特定大脑区域.
主要方法:
- 记录了在虚拟环境中导航的子的单个单元刺活动.
- 同时记录从背中侧上区 (MSTd),额头区域7a和背侧前额叶皮层 (dlPFC).
- 对感觉 (光流) 与内部模型的操纵依赖,并分析了神经统计依赖和功能连接.
主要成果:
- 子保持了适应性的信念,而不管感官背景.
- 在平面区域7a和dlPFC中的神经统计依赖性随着计算需求的变化而动态重新映射.
- 在dlPFC中破坏这些依赖关系会损害跨上下文解码,而MSTd则显示更少的重映射.
- 增加dlPFC的重新映射和减少MSTd的重新映射与从感官证据损失中减少的行为影响相关.
结论:
- 前额叶皮层内的动态功能连接对于保持稳定的人口代码和不变背景的信念至关重要.
- 大脑灵活地整合了感官信息和内部模型,以支持适应性行为.
- 神经电路动力学,特别是在dlPFC中,在自然主义任务中的认知灵活性中起着至关重要的作用.
更多相关视频
04:43Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset
Published on: February 1, 2019
9.6K
08:36Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
Published on: March 21, 2019
7.3K
相关概念视频
01:16Cell Motility through Blebbing
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
01:03Basal Lamina are the Specialized Form of ECM
The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
Proteins...
01:15Activation of Integrins
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
01:06Multipotency and Niche of Bulge Stem Cell
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
01:16Accessory Structures of the Skin: Hair and Hair Follicles
Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
01:24Facial Feedback Hypothesis
Charles Darwin proposed that facial expressions are an evolutionary adaptation for communication. He argued that these expressions are not influenced by culture but are universal across species. For example, a snarling expression with exposed teeth signals a threat in many animals, including humans. Darwin also suggested that displaying an emotion can intensify the feeling. Smiling, for example, could enhance one's sense of happiness. This idea laid the foundation for understanding the role of...