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Updated: Jun 21, 2025

Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling
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Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling

Published on: October 28, 2014

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m3C32的tRNA修饰控制了血清编码子偏差的mRNA转化,细胞循环和DNA损伤反应

Jia Cui1,2, Erdem Sendinc1,2, Qi Liu1,2,3,4

  • 1Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, 02115, USA.

Nature communications
|July 9, 2024
PubMed
概括

这项研究揭示了转移RNA (tRNA) 上的N3-甲基丁 (m3C) 如何影响基因表达. METTL2A/2B/6酶对m3C修饰至关重要,影响细胞周期和DNA修复基因翻译.

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