相关实验视频

Updated: Apr 24, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

在阿尔茨海默病早期阶段的小鼠模型中,ErbB4缺乏会加剧嗅觉功能障碍

Xian-Hua Deng^1,2, Xing-Yang Liu^1,2, Yi-Hua Wei^1,2

¹Center for Brain Sciences, The First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361000, China.

Acta pharmacologica Sinica

|July 9, 2024

概括

阿尔茨海默病 (AD) 中的嗅觉功能障碍与嗅觉灯泡 (OB) 中的神经调节素1 (NRG1) /ErbB4信号受损有关. 恢复这种途径可以缓解小鼠早期与阿尔茨海默病相关的嗅觉丧失.

科学领域:

神经科学是一个神经科学.
阿尔茨海默氏症疾病研究研究
嗅觉系统生物学嗅觉系统生物学

背景情况:

嗅觉功能障碍是阿尔茨海默病 (AD) 的早期指标.
嗅球 (OB) 中的GABAergic功能和E/I平衡与AD相关的嗅障碍有关.
神经调节蛋白1 (NRG1) /ErbB4通路调节大脑GABAergic传输,但其在早期AD嗅觉功能障碍中的作用尚不清楚.

研究的目的:

调查NRG1/ErbB4信号在早期AD相关的嗅觉功能障碍中的作用.
为了确定ErbB4缺失在parvalbumin内部神经元对OB功能和嗅觉性能在AD的小鼠模型的影响.
探索向NRG1/ErbB4通路的治疗潜力,用于早期AD的嗅觉缺陷.

主要方法:

使用了年轻的成年APP/PS1小鼠,这是早期AD的模型.
评估嗅觉功能和认知能力下降.
在OB中测量NRG1和ErbB4水平.
研究了ErbB4删除在parvalbumin内部神经元对OB兴奋性和GABAergic传播的影响.
分析了Aβ积累,BACE1裂变和CDK5信号.
将NRG1注入OB以评估其治疗效果.

主要成果:

嗅觉功能障碍在APP/PS1小鼠的认知衰退之前,OB NRG1和ErbB4水平降低.
在parvalbumin内部神经元中的ErbB4缺失导致GABAergic传输受损,增加OB过敏性,加快嗅觉功能障碍.
在OB中,ErbB4缺乏与Aβ负荷增加,BACE1活性和CDK5信号相关.
在APP/PS1小鼠中,NRG1输液增强了OB GABAergic传输,改善了嗅觉功能障碍.

结论:

NRG1/ErbB4信号传递对于调节OB GABAergic传输和E / I平衡至关重要,影响AD早期的嗅觉功能.
埃尔比B4缺乏症通过破坏GABAergic抑制和破坏OB E/I平衡,加剧AD病理和嗅觉缺陷.
针对NRG1/ErbB4通路提供了早期干预AD相关嗅觉功能障碍的潜在策略.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.在GABAergic传输过程中,有活性的 GABA.在NRG1/ErbB4信号传输中.激发/抑制 (E/I) 不平衡嗅觉障碍是一种嗅觉障碍.

更多相关视频

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Published on: June 17, 2015

Simple and Computer-assisted Olfactory Testing for Mice

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

相关概念视频

Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

Olfactory Receptors: Location and Structure

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

Alzheimer Disease ll: Pathophysiology

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...