口腔微生物组与HPA轴对心理社会压力因素的反应有关
Eleftheria G Charalambous1,2,3,4, Sophie B Mériaux1, Pauline Guebels1
1Immune Endocrine Epigenetics Research Group, Department of Infection and Immunity, Luxembourg Institute of Health, 29, rue Henri Koch, 4354, Esch-sur-Alzette, Luxembourg.
Scientific reports
|July 9, 2024
概括
早期的生活压力会影响长期健康. 这项研究揭示了口腔微生物组影响身体的应激反应,影响成人皮质醇和葡萄糖水平.
科学领域:
- 微生物组研究 微生物组研究
- 神经内分泌学神经内分泌学
- 人类的新陈代谢.
背景情况:
- 早期的心理社会压力会对长期的健康和疾病平衡产生负面影响.
- 发育中的微生物群对压力敏感,并对长期健康起到作用.
- 脑下垂体-垂体-上腺 (HPA) 轴的激活,涉及葡萄糖和皮质醇的释放,介导着脑下垂体-垂体-上腺 (HPA) 轴的激活.
- 战斗或逃跑的选择
- 应对压力的反应.
研究的目的:
- 研究口腔微生物组与宿主应激反应之间的相互作用.
- 为了确定特定的口腔微生物种类是否会影响对急性压力的生理反应.
主要方法:
- 研究了一组115名成年人 (平均年龄24岁),包括收养的个人 (n=40) 和未收养的对照 (n=75).
- 参与者接受了扩展的社会评估冷压力测试 (seCPT),多次测量葡萄糖和皮质醇.
- 分析了口腔微生物组的组成,使用唾液和口腔样本的16S-V4测序.
主要成果:
- 混合效应线性回归确定了12个口腔微生物属,它们与宿主的皮质醇-葡萄糖应激反应相互作用.
- 这些类在seCPT后显著影响了皮质醇和葡萄糖的强度和清除率.
- 发现特定的种类调节了葡萄糖和皮质醇应激后暴露的释放概况和动力学.
结论:
- 口腔微生物组在调节压力对HPA轴和人类新陈代谢的生理影响方面发挥着作用.
- 研究结果表明,口腔微生物组成与身体对急性压力的动态葡萄糖和皮质醇反应之间存在联系.
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