假定结核淋巴腺炎患者的细胞形态学模式和临床特征及其与细菌学检测方法的比较:一个横截面研究
Abay Atnafu1, Liya Wassie2, Melaku Tilahun2
1Armauer Hansen Research Institute, Addis Ababa, Ethiopia. ayatab.ayele7@gmail.com.
BMC infectious diseases
|July 9, 2024
概括
细胞形态特征与细菌学方法诊断结核淋巴结核炎 (TBLN) 强烈一致. 仅仅临床表现可能导致误诊,这强调了细胞形态学在TBLN诊断中的重要性.
科学领域:
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
- 微生物学 微生物学
背景情况:
- 结核性淋巴腺炎 (TBLN) 是由Mycobacterium tuberculosis引起的全球重大健康问题.
- 组织病理学和细胞形态学特征对于诊断TBLN至关重要,但它们的诊断准确性可能受到变异性的限制.
- 将细胞形态学发现与确定的细菌学方法进行比较对于提高诊断可靠性至关重要.
研究的目的:
- 研究和比较结核性淋巴腺炎 (TBLN) 的细胞形态特征与已建立的细菌学检测方法.
- 在假定的TBLN病例中评估特定细胞形态模式 (A,B和C) 的诊断效用.
- 评估临床症状与TBLN的细菌学确认之间的相关性.
主要方法:
- 分析了可能的TBLN患者的前性队列.
- 用精细针吸收细胞学 (FNAC) 来评估细胞形态特征.
- 使用GeneXpert和MGIT培养方法进行了细菌学确认.
- 统计分析,包括描述性统计和千平方测试,使用SPSS版本26进行.
主要成果:
- 在47.6%的参与者中,FNAC确定了与TBLN一致的特征.
- 模式B (状死) 和C (状颗粒瘤与状死) 是最常见的FNAC发现.
- 细胞形态模式A,B和C与GeneXpert和MGIT培养结果有很强的一致性 (P<0.001).
- 在所有方法中,夜间出汗和酒精摄入与积极的TBLN诊断有显著的关联.
结论:
- 细胞形态模式A,B和C是诊断TBLN的可靠指标,其结果与细菌学方法相似.
- 仅仅依靠临床表现来诊断TBLN可能会误导,并可能导致不适当的治疗.
- 将细胞形态学分析与细菌学确认相结合,可以提高TBLN诊断和管理的准确性.
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