上腺体体积和脂肪组织部分之间的关联 - 全身MRI研究
Esther Askani1, Susanne Rospleszcz1,2,3, Roberto Lorbeer4
1Department of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Nutrition & metabolism
|July 9, 2024
概括
通过MRI测量上腺体体积,与不健康的脂肪分布有关,独立于代谢问题. 这种成像标记可能有助于评估代谢健康和分层个体风险.
科学领域:
- 放射学和成像学 放射学和成像学
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
背景情况:
- 肥胖与下丘脑-垂体-上腺 (HPA) 轴的变化有关.
- 葡萄糖皮质醇对脂肪组织的影响因体积而异.
- 基于MRI的上腺体体积作为脂肪组织部分标记物的研究.
研究的目的:
- 探索MRI确定上腺体体积与各种脂肪组织储存之间的关联.
- 评估上腺体体积作为潜在的成像生物标志物对代谢健康.
主要方法:
- 来自KORAMRI子研究的400名参与者的横截面研究.
- 全身MRI用于细分上腺体体积,内脏脂肪组织 (VAT),皮下脂肪组织 (SAT) 和其他脂肪储存.
- 测量肝脏和胰腺脂肪含量.
- 多变量线性回归分析.
主要成果:
- 在对混因素进行调整后,上腺体体积与内脏脂肪组织 (VAT),总脂肪组织 (TAT) 和肝脂肪分数 (HFF) 呈现出强烈的正相关性.
- 在BMI调整后,与皮下脂肪组织 (SAT) 的关联减弱.
- 增值税在很大程度上调解了其他脂肪储存 (胰腺,心表,心周, sinus) 和上腺体体积之间的联系.
结论:
- 基于MRI的上腺体体积可以作为对不良脂肪组织分布的成像生物标志物,无论代谢风险因素如何.
- 上腺体体积可能是潜在的MRI生物标志物,用于代谢变化和个体风险分层.
- 需要进行进一步的纵向研究,以澄清HPA轴激活在脂肪组织分布和代谢综合征发病过程中的作用.
相关概念视频
01:17Anatomy of the Adrenal Glands
2.2K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
2.2K
01:24Magnetic Resonance Imaging
5.1K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.1K
01:02Hypodermis
4.3K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
4.3K