体重,习惯性纤维摄入量和微生物组合可以预测人们对果糖补充剂的耐受性
Jeffrey Letourneau1, Benjamin C Neubert2, Diana Dayal3
1Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.
International journal of food sciences and nutrition
|July 10, 2024
概括
果糖补充剂,如胰岛素可以引起副作用,但耐受性各不相同. 更高的体重和习惯性纤维摄入量可以提高耐受性,而特定的肠道细菌会影响副作用.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 果实素,包括胰岛素,被广泛用作食纤维补充剂,以增强有益的肠道微生物群.
- 然而,果糖消费与剂量依赖的胃肠道副作用有关.
研究的目的:
- 在健康的成年人中描述与胰岛素消费相关的副作用.
- 探索宿主因素,肠道微生物组组成和对胰岛素的耐受性之间的关系.
主要方法:
- 一项随机对照试验的探索性分析,该试验涉及40名健康成年人,每天摄入18g的胰岛素或安慰剂.
- 分析宿主因素 (体重,习惯性纤维摄入量) 和肠道微生物组合.
- 应用机器学习方法来预测诸如气胀等副作用.
主要成果:
- 体重较高,习惯性纤维摄入量较高的人对胰岛素的耐受性更好.
- 特定的肠道细菌与宿主耐受性有关:较高的克里斯森氏菌R-7组与胃肠道不适相关.
- 机器学习成功地预测了高气水平,识别了[Ruminococcus]扭矩组和UCG-002 sp. 作为一个关键的预测类型.
结论:
- 主体因素和肠道微生物组合影响了对胰岛素补充剂的耐受性.
- 这些发现可以为个性化的胰岛素剂量建议提供信息.
- 纤维补充对基线纤维摄入量较低的个体的影响最大.
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