相关实验视频
Updated: Jun 21, 2025

07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
8.1K
在儿童和成人中毒免疫治疗期间的临床特征,严重程度和免疫学变化
Betul Buyuktiryaki1, Francesko Hela2, Ayse Bilge Ozturk3
1From the Division of Pediatric Allergy, School of Medicine, Department of Pediatrics, Koc University, Istanbul, Turkey.
Allergy and asthma proceedings
|July 10, 2024
概括
黄虫毒素过敏 (HVA) 在成人和儿童中呈现不同的临床模式. 毒素免疫疗法 (VIT) 有效诱导强烈的IgG4反应,特定的毒素免疫疗法引发相应的IgG4增加.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
- 临床医学 临床医学
背景情况:
- 黄虫毒素过敏 (HVA) 是全球严重过敏反应的普遍原因.
- 了解HVA的临床表现和风险因素对于有效管理至关重要.
研究的目的:
- 调查HVA的临床特征和严重性因素.
- 评估在毒素免疫疗法 (VIT) 后免疫生物标志物的改变.
主要方法:
- 在76名成人和36名患有HVA的儿童中进行了前性研究.
- 在VIT之前和一年后对毒液提取物和成分的特定IgE (sIgE) 和IgG4水平的分析.
主要成果:
- 成年人表现出更多的心血管症状,而儿童的皮肤受影响更大.
- 缺少疹和血清基础合酶 (sBT) ≥5.2 ng/mL是严重 (IV级) 反应的危险因素.
- 维特诱导了毒素特异性IgG4水平的显著增加,其中Apis VIT主要增强了Apis sIgG4 (不包括Api m10),而Vespula VIT增强了Vespula和Polistes sIgG4.
结论:
- 在成人和儿童中,HVA的临床表现不同.
- 一年VIT有效诱导强大的IgG4免疫反应.
- 特定毒素免疫疗法引起了向的IgG4反应,在Vespula免疫疗法中观察到交叉反应.
相关概念视频
Allergic Reactions
27.3K
Overview
27.3K
Hypersensitivities
579
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
579
Tumor Immunotherapy
509
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
509
Cross-reactivity
31.0K
Overview
31.0K
Immunodeficiency Diseases
933
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
933
Immunological Memory
584
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
584

