化疗前后儿童固体瘤中贫血的模式 - 一个回顾性队列研究
Tomal Barman Aron1, Sagor Kumar Roy2, Shuting Mao1
1Department of Pediatrics, First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou, 450000, PR. China.
Current cancer drug targets
|July 10, 2024
概括
贫血常见于患有固体瘤的儿童,特别是神经母细胞瘤和肝母细胞瘤. 骨髓干扰和化疗可以使贫血恶化,这表明儿童癌症患者需要向性贫血治疗.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
背景情况:
- 固体儿科瘤在诊断和治疗方面存在独特的挑战.
- 贫血是患有这些癌症的儿童的一个重大问题.
- 了解贫血的原因对于有效的患者管理至关重要.
研究的目的:
- 研究患有固体瘤的儿科患者贫血的原因和表现.
- 评估这些患者化疗前后的血液参数.
- 探索贫血,血清费里丁,体重和骨髓转移之间的关系.
主要方法:
- 对235名儿科固体瘤患者和200名健康对照者的回顾性队列研究.
- 在化疗前和后对血液成分 (血红蛋白,红细胞,白细胞,血小板) 的分析.
- 在特定瘤类型中评估血清费里,体重和骨髓参与.
主要成果:
- 在患有骨髓母细胞瘤,神经母细胞瘤,狂宫肌肉瘤,生殖细胞瘤,肝母细胞瘤和神经母细胞瘤的患者中观察到各种血液参数异常.
- 在年轻的神经母细胞瘤患者 (p=0.022) 中发现血清费里丁与体重之间的相关性.
- 确认的骨髓瘤参与与神经母细胞瘤和肝母细胞瘤中的血红蛋白降低显著相关 (p=0.001).
结论:
- 贫血可能是神经母细胞瘤,肝母细胞瘤和母细胞瘤的早期指标.
- 化疗可能会加剧神经母细胞瘤和肝母细胞瘤患者的贫血.
- 贫血管理和治疗对于儿科癌症患者至关重要.
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