宫内系统激素剂量与抑郁症风险之间的关联
Søren Vinther Larsen1, Anders Pretzmann Mikkelsen1, Brice Ozenne1
1Neurobiology Research Unit (Larsen, Ozenne, Frokjaer) and Department of Gynecology, Fertility, and Obstetrics, Juliane Marie Center (Mikkelsen, Lidegaard), Copenhagen University Hospital, Rigshospitalet, Copenhagen; Department of Clinical Medicine (Larsen, Lidegaard, Frokjaer) and Department of Public Health, Section of Biostatistics (Ozenne), University of Copenhagen, Copenhagen; Department of Gynecology and Obstetrics, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark (Mikkelsen); Psychiatric Research Unit, Department of Clinical Research, University of Southern Denmark, Odense (Munk-Olsen); National Center for Register-Based Research, Aarhus University, Aarhus, Denmark (Munk-Olsen); Psychiatric Center Copenhagen, Mental Health Services in the Capital Region of Denmark, Copenhagen (Frokjaer).
第一次使用levonorgestrel释放子宫内系统 (LNG-IUSs) 的女性,患抑郁症的风险增加. 这种风险在增加LNG-IUS剂量时更高,这表明剂量依赖关系.
科学领域:
- 生殖健康 生殖健康
- 心理健康 心理健康
- 药物监督 药物监督 药物监督
背景情况:
- levonorgestrel释放子宫内系统 (LNG-IUSs) 被广泛用于避孕.
- 了解潜在的心理健康副作用,如抑郁症,对于患者咨询和知情决策至关重要.
研究的目的:
- 为了比较低,中,高剂量液化天然气IUS首次使用者中发生抑郁症的风险.
- 调查LNG-IUS使用和抑郁风险之间的潜在剂量反应关系.
主要方法:
- 一项使用2000-2022年丹麦登记数据的国家队列研究.
- 包括年龄在15-44岁之间的首次LNG-IUS用户.
- 采用考克斯回归和G公式估计器来计算抑郁症的1年风险,风险差异和风险比率,并对各种共同变量进行调整.
主要成果:
- 149,200名妇女开始使用LNG-IUS.
- 一年调整后的绝对抑郁风险为1.21% (低剂量),1.46% (中剂量) 和1.84% (高剂量).
- 高剂量与低剂量和中剂量LNG-IUS的风险比分分别为1.52和1.26. 中剂量与低剂量的风险比率为1.21.
结论:
- 第一次使用LNG-IUS与剂量依赖的方式增加发生抑郁症的风险有关.
- 这些发现有助于证据表明levonorgestrel暴露和抑郁风险之间存在联系,尽管因果推断受到观察设计的限制.
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