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在健康的对照人群中对定量肌肉磁共振成像进行前性纵向队列研究

Johannes Forsting¹, Robert Rehmann^1,2, Marlena Rohm^1,3

¹Department of Neurology, BG-University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany.

NMR in biomedicine

|July 10, 2024

概括

定量肌肉MRI (qMRI) 和扩散张力成像 (DTI) 是可靠的评估肌肉健康超过18个月的健康成年人. 这些先进的成像技术显示出一致的结果,为肌肉变异建立了基准.

科学领域:

生物医学工程生物医学工程
放射学放射学是一门学科.
运动医学运动医学

背景情况:

定量肌肉磁共振成像 (qMRI) 对于评估肌肉损伤和神经肌肉疾病至关重要.
肌肉扩散张力成像 (DTI) 提供了对肌肉微观结构和宏观结构的详细见解.
qMRI和DTI指标的长期可重现性和稳定性需要进一步研究.

研究的目的:

评估qMRI参数的长期稳定性和变化,特别是DTI指标.
为了在现实生活条件下评估健康对照的下肢肌肉中的这些参数.
为期望 qMRI 参数随时间变化建立一个基准.

主要方法:

对12名健康志愿者进行了长达1.5年的前性纵向队列研究.
每20 ± 4周进行5次MRI,使用多回声迪克森,T2映射和DTI序列.
两侧分成15个腿部肌肉;分析了qMRI参数 (脂肪分数,T2放松时间,FA,MD).

主要成果:

所有的qMRI参数都显示了所有肌肉的良好可重现性 (wsCV ≤10%).
在FF (0.980),水T2 (0.941),FA (0.952) 和MD (0.948) 的时间点之间观察到非常好的一致性.
较低的随机测量误差 (SEM,MDC <12%) 表示高可靠性.

结论:

包括DTI指标在内的qMRI参数在18个月的时间内在健康人群中保持稳定.
这项研究为肌肉qMRI参数的预期变化范围建立了可靠的基准.
这些发现支持使用qMRI和DTI进行肌肉健康的纵向监测.

关键词:

纵向队列研究是一项纵向队列研究.肌肉扩散张力成像张力成像这是骨肌肉的骨架肌肉.路径学路径学路径学路径学路径学

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