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Updated: Jun 21, 2025

Author Spotlight: Unraveling the Dynamics of Eukaryotic DNA Replication Through Single-Molecule Visualization
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Published on: September 27, 2024

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识别ATP-竞争性人类CMG酶抑制剂用于癌症干预,破坏CMG-复原体功能

Shengyan Xiang1,2, Kendall C Craig2,3, Xingju Luo1,2

  • 1Cancer Biology and Evolution Program, Moffitt Cancer Center and Research Institute, Tampa, Florida.

Molecular cancer therapeutics
|July 10, 2024
PubMed
概括

新的CMG抑制剂 (CMGi) 向CMG螺旋酶,这是一种新的抗癌治疗点. 这些MCM复合抑制剂 (MCMi) 破坏DNA复制并选择性地杀死瘤细胞,提供了一种新的治疗方法.

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