甲状腺功能与非酒精性脂肪肝疾病之间的关联:剂量反应元分析
Liu-Lan Xiang1,2, Yu-Tian Cao1,2, Jing Sun1,2
1Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
Frontiers in endocrinology
|July 10, 2024
概括
甲状腺激素与非酒精性脂肪性肝病 (NAFLD) 有关. 较高的自由甲状腺素 (FT4) 可能会降低NAFLD风险,而高甲状腺刺激激素 (TSH) 与肝纤维化有关.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 在全球范围内,非酒精性脂肪性肝病 (NAFLD) 的患病率越来越高.
- 甲状腺激素 (THs) 参与NAFLD的发病,但确切的关系尚不清楚.
- 了解TH水平与NAFLD之间的关联对于患者管理至关重要.
研究的目的:
- 进行一项元分析,评估甲状腺功能与NAFLD风险之间的相关性.
- 为了研究甲状腺激素水平和NAFLD之间的剂量反应关系.
- 评估甲状腺激素水平与NAFLD患者肝纤维化之间的关联.
主要方法:
- 在PubMed,科学网,科克兰图书馆和Embase的系统文献搜索.
- 包含了10项研究,共38425名参与者.
- 综合整体和剂量反应元分析以评估TH水平和NAFLD风险.
主要成果:
- 增加的自由甲状腺素 (FT4) 与NAFLD风险降低有关 (10.56%的降低,每增加1ng/dL).
- 较高的自由三甲状腺素 (FT3) 水平与较高的NAFLD风险相关 (OR=1.580).
- 甲状腺刺激激素 (TSH) 的升高与明显更高的肝纤维化水平有关 (SMD=1.32).
结论:
- 甲状腺激素水平异常与NAFLD发生之间存在相关性.
- 特定的甲状腺激素水平,如FT4和FT3,与NAFLD风险有明显的关联.
- 需要进一步的观察性研究来阐明甲状腺激素和NAFLD之间的复杂关系.
相关概念视频
01:18Functions of Thyroid Hormones
2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K
01:20Synthesis and Regulation of Thyroid Hormones
4.5K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.5K
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
95
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
95
01:26Diseases of the Liver and Gallbladder
507
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
507
01:24Overview of Lipid Metabolism
1.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.3K
01:22Target Cell Response to Hormones
3.0K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
3.0K