相关实验视频
Updated: Jun 21, 2025

07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
68
类风湿性关节炎中的硬化症:在生物学时代之前和期间
Daphne P C Vergouwen1,2, Pascal H P de Jong3, Marco W J Schreurs2
1Department of Ophthalmology, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Frontiers in ophthalmology
|July 10, 2024
概括
风湿性关节炎 (RA) 中的硬化症发病率在生物时代下降,但仍然严重. 在RA患者中,硬化症的临床表现和死亡率与生物学前时代相似.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 临床医学 临床医学
背景情况:
- 硬化症是类风湿性关节炎 (RA) 的一种严重的关节外表现.
- 最近的观察表明,RA患者的硬化症发病率正在下降,这可能是由于先进的治疗方法.
- 本研究探讨了生物时代和其历史背景下的RA硬化症.
研究的目的:
- 为了确定生物时代在类风湿性关节炎 (RA) 患者中结核炎的发病率.
- 分析RA中硬化性硬化症的临床特征和结果.
- 为了比较当前的发现与前生物学时代的历史数据.
主要方法:
- 在2011年至2021年期间诊断出1623名RA患者的回顾性分析.
- 对RA患者的临床和实验室数据的审查.
- 文献综述以比较发现与前生物学时代.
主要成果:
- 在RA中硬化症的发病率在10年 (2011-2021) 中为0.25%.
- 结核炎的表现和并发症,包括结核性亡 (>80%),仍然严重,与生物学前时代相似.
- 在9年内,RA患者的死亡率为30%,相当于生物学前时代的死亡率. 自体抗体和侵蚀性疾病是常见的.
结论:
- 虽然RA中的硬化性硬化症发病率在生物时代可能略低,但其临床严重程度仍然存在.
- 眼科医生和风湿病学家必须保持警,以寻找硬化症作为RA的严重表现.
- 尽管治疗方面取得了进展,但RA中硬化症的临床表现和结果没有显著变化.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
128
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
128
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
156
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
156
Inflammatory Bowel Disease IV: Pharmacological Management
125
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
125
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
114
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
114
T Cell Types and Functions
996
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
996
Inflammatory Bowel Disease II: Crohn's Disease
212
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
212

