尼福帕姆作为胸腔镜手术中的多模式止痛药:一项随机对照试验
Hyun-Seo Ki1, Jae-Geum Shim1, Hyung-Kyeong Choi1
1Department of Anesthesiology and Pain Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Journal of thoracic disease
|July 10, 2024
概括
尼福帕姆在接受视频辅助胸腔镜手术 (VATS) 的患者中有效降低了术后疼痛. 这种非阿片类止痛药改善了休息和咳时的疼痛评分,有助于VATS手术后的恢复.
科学领域:
- 麻醉学 麻醉学
- 胸部外科手术 胸部外科手术
- 疼痛管理 疼痛管理
背景情况:
- 视频辅助胸腔镜手术 (VATS) 是最少的侵入性,但可以引起显著的术后疼痛.
- 后VATS疼痛可以阻碍恢复,增加肺部并发症的风险.
- 多学科疼痛管理对于增强VATS后恢复至关重要.
研究的目的:
- 在VATS中评估nepopam作为多式联络止痛的一部分的疗效.
- 为了确定nefopam是否降低了VATS叶切除术患者的疼痛评分.
- 评估nefopam对休息和咳后VATS疼痛的影响.
主要方法:
- 一项随机,双盲研究,涉及46名预定接受选择性VATS脑膜切除术的患者.
- 参与者被分配给接受nefopam (20毫克) 或盐水安慰剂.
- 疼痛评分是通过口头数值评分表在手术后的不同时间点进行评估的.
主要成果:
- 尼福帕姆在0小时 (P=0.01) 和0-1小时 (P=0.001) 显著减少了休息时的疼痛.
- 咳后的疼痛在0小时 (P=0.009),0-1小时 (P=0.001) 和12-24小时 (P=0.03) 中减少了nefopam.
- 在切口前和手术结束时服用nefopam显示出显著的疼痛缓解.
结论:
- 尼福帕姆是一种有效的非阿片类止痛药,用于管理VATS后的术后疼痛.
- 它可以成为多模式止痛策略的宝贵组成部分.
- 尼福帕姆有助于改善疼痛控制,并可能增强VATS后的恢复.
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