术前呼吸评估预测了在非小细胞肺癌IA期的术后生存率
Mototsugu Watanabe1, Tomoki Tamura2, Noriaki Shiraha1
1Department of Thoracic Surgery, National Hospital Organization Iwakuni Clinical Center, Iwakuni, Yamaguchi, Japan.
Journal of thoracic disease
|July 10, 2024
概括
限制性呼吸系统功能障碍会对肺癌手术后的存活率产生负面影响. 然而,阻塞性损伤并没有显著影响患者的无复发存活率或整体存活率. 仔细的手术规划至关重要.
科学领域:
- 胸部外科手术 胸部外科手术
- 肺部医学 肺部医学
- 在瘤学瘤学.
背景情况:
- 手术前的呼吸功能对于肺癌的手术决定至关重要.
- 根据呼吸系统状况选择适当的外科手术的指标有限.
- 手术后的并发症和生存结果是肺切除后的关键问题.
研究的目的:
- 调查手术前呼吸功能与术后结果之间的关联,在接受肺切除的第一阶段肺癌患者中.
- 分析呼吸功能对早期和晚期并发症,无复发生存率 (RFS) 和整体生存率 (OS) 的影响.
主要方法:
- 对192名患有IA期非小细胞肺癌 (NSCLC) 的患者进行了回顾性分析.
- 在2012-2015年期间在日本Iwakuni临床中心收集的数据.
- 评估临床病理学特征,包括术前肺功能,以及它们与生存的关系.
主要成果:
- 阻塞性呼吸功能障碍 (28.6%) 并没有显著影响5年RFS或OS.
- 限制性呼吸功能障碍 (16.1%) 显著减少了5年的RFS (P=0.002) 和OS (P=0.009).
- 根据手术前的呼吸功能,早期或晚期并发症率没有显著差异.
结论:
- 限制性呼吸功能障碍需要仔细考虑肺癌切除中的手术指示.
- 具有限制性功能障碍的患者可能会从替代治疗策略或修改的外科手术方法中受益.
- 术前肺功能评估对于优化肺癌患者手术结果至关重要.
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