使用PSM分析外部有害物质暴露作为COPD和高血压共患病的风险因素
Qingyang Chen1, Haodong Zhou1, Jiarong Tang1
1Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, China.
Frontiers in public health
|July 10, 2024
概括
暴露于有害物质会增加慢性阻塞性肺病 (COPD) 和高血压并发症的风险. 倾向性得分匹配揭示了这一显著的关联,强调了在职业和环境健康方面需要采取保护措施的必要性.
科学领域:
- 环境健康 环境健康
- 职业医学 职业医学是专业的.
- 肺部病理学 肺部病理学
- 心脏病学 心脏病学
背景情况:
- 职业和环境暴露与慢性阻塞性肺病 (COPD) 和高血压的风险增加有关.
- 多重有害物质暴露对COPD和高血压共患病率的综合影响仍未得到充分研究.
研究的目的:
- 调查暴露于外源有害物质和COPD和高血压的共同病症之间的关联.
- 确定导致COPD和高血压在中国人口中同时发生的风险因素.
主要方法:
- 一个多阶段的集群采样,来自中国八家医院的6610名参与者.
- 倾向性得分匹配 (PSM) 用于暴露和非暴露组之间的1:1匹配.
- 分析包括千二测试和多因素后勤回归,用于对金属,尘埃,化学品和副产品的暴露.
主要成果:
- 外源性有害物质暴露被确定为PSM后COPD和高血压共患病的显著风险因素 (OR = 1.347,95% CI: 1.011-1.794).
- 与总人口 (4.6%) 相比,暴露组 (6.0%) 的并发症患病率更高.
- 吸烟,儿童呼吸系统疾病史和呼吸系统症状也是显著的危险因素.
结论:
- 暴露于外源有害物质是COPD和高血压并发症的关键风险因素,特别是在调整人口统计因素后.
- 伴随性疾病的患病率在暴露于有害物质的敏感人群中较高.
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