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在中国老年人中,年龄和估计的膜过率:从2014年到2020年的队列研究
Ying Jiang1, Qin Cao2, Weiqi Hong3
1Department of Clinical Nutrition, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in public health
|July 10, 2024
概括
在中国老年人中,功能 (eGFR) 随着年龄的增长而下降,在女性中更快. 高血压加速衰退;肥胖和某些脂质水平也会影响男性和女性的功能.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
背景情况:
- 功能自然会随着年龄的增长而下降,但关于其在老年人中的过程的数据仍然不完整,特别是在不同的健康状况中.
- 了解与年龄相关的功能变化对于老年护理和疾病预防至关重要.
研究的目的:
- 为了研究中国老年人估计的球过率 (eGFR) 降低的轨迹.
- 检查各种健康指标如何影响与年龄相关的功能下降的速度.
主要方法:
- 一项对5112名中国老年人 (60-104岁) 的观察性回顾性队列研究.
- 线性混合效应模型被用于分析个人eGFR随时间的下降率,并考虑重复测量.
主要成果:
- 随着年龄的增长,eGFR线性下降:女性1.06毫升/分钟/1.73毫升/年,男性0.91毫升/分钟/1.73毫升/年.
- 较高的缩血压 (SBP) 与两性中更快的eGFR下降有关.
- triglycerides (TG) 高,LDL-C 高,HDL-C 低的男性和肥胖女性显示出加速的EGFR下降.
- 与较低基线eGFR的人相比,基线eGFR正常的个体经历了较快的与年龄相关的衰退.
结论:
- 在中国老年人中,功能随着年龄的增长而逐渐下降,在女性中观察到的速度略快一些.
- 关键的健康因素,如SBP,脂质样本 (男性),肥胖 (女性) 显著改变与年龄相关的eGFR下降.
- 监测功能是必不可少的,特别是对于基线正常功能,高SBP,失脂症或肥胖的老年人来说.
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