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针对COVID-19的疫苗接种对年轻人膀过活症状的影响
Marta de-la-Plaza-San-Frutos1,2, Elisa García-García1,3, Beatriz Martínez-Pascual1
1Faculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain.
Frontiers in medicine
|July 10, 2024
概括
接种COVID-19疫苗可能会影响尿路,最初会导致过度活跃的膀症状恶化. 症状随着后续剂量改善,显示某些疫苗的性别特异性影响.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- COVID-19疫苗的向是尖蛋白,有报道的副作用.
- 了解潜在的尿路副作用对于公共卫生战略至关重要.
- 研究疫苗对尿路功能的影响可以改善疫苗接种计划.
研究的目的:
- 调查COVID-19疫苗接种对下泌尿道症状 (LUT) 和膀过活 (OAB) 的影响.
- 分析潜在的性别特异性影响和剂量依赖性反应.
- 用OABSS-S来评估尿路症状的变化,使用过度活性膀症状评分 (OABSS-S).
主要方法:
- 对2,362名参与者进行了在线调查,其中1,563人被排除后纳入调查.
- 参与者通过OABSS-S.提供了疫苗接种状态 (剂量,类型),COVID-19病史和尿道症状的数据.
- 收集了包括性别和年龄 (18-45岁) 在内的人口统计数据.
主要成果:
- 在45岁以下的个人接种了第一剂疫苗后,观察到LUT症状的初始恶化和OABSS-S得分的增加.
- 在接种了第三次和第四次疫苗后,尿路症状有所改善.
- 性别差异出现了:阿斯特拉泽内卡疫苗接种者报告了更多的夜间空白 (男性),而Moderna接种者报告了更多的白天空白 (女性).
结论:
- 接种COVID-19疫苗可能会影响下泌尿道和膀过活.
- 症状严重程度最初在接种疫苗后增加,但随着补充剂量得到改善.
- 观察到的性别特异性影响凸显了有关疫苗接种和尿道健康的个性化健康策略的需要.
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