怀孕期间母亲吸烟和智力障碍的后代风险:一项英国的队列研究
Paul Madley-Dowd1,2,3, Richard Thomas4, Andy Boyd4
1Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Frontiers in psychiatry
|July 10, 2024
概括
怀孕期间母亲吸烟与后代的智力障碍 (ID) 没有因果关系. 英国的一项大型研究没有发现因果关系的证据,这表明其他因素也可能参与其中.
科学领域:
- 生殖健康 生殖健康
- 发育神经科学的发展神经科学.
- 流行病学 流行病学
背景情况:
- 观察性研究表明,孕妇在怀孕期间吸烟与后代的智力障碍 (ID) 有关.
- 这种关联的因果性仍然不确定,并有可能产生未测量的混.
- 澄清这种关系对于公共卫生指导和干预至关重要.
研究的目的:
- 调查怀孕期间母亲吸烟与后代智力障碍 (ID) 之间的因果关系.
- 在观察到的关联中区分真正的因果关系和混因素.
- 为产前护理建议提供基于证据的结论.
主要方法:
- 利用了总部位于英国的有望出生队列 (Avon长度研究父母和孩子) 与13,479名儿童.
- 通过使用链接的健康和教育记录,评估了怀孕18周的母亲吸烟情况和后代的ID.
- 雇佣混调整后勤回归和负对照分析,比较母亲和伴侣吸烟.
主要成果:
- 观察分析显示,母亲吸烟与后代智商之间没有显著的关联 (OR 0.75-0.97).
- 对比母亲和伴侣吸烟的负对照分析产生了可比的,非显著的影响估计 (OR 0.94).
- 结果表明,影响两种暴露的偏差可能解释了观察到的关联.
结论:
- 这些发现不支持母亲在怀孕期间吸烟对后代智力障碍的因果关系.
- 观察到的关联很可能归因于母体和伴侣吸烟中共同的混因素或偏见.
- 这项研究强调了严格的方法论在观察性研究中建立因果关系的重要性.
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