新发性败血症中的25-氧维生素D和副甲状腺激素:一项针对重症患者的前性研究
Irene Karampela1,2, Theodora Stratigou2,3, Georgios Antonakos4
1Second Department of Critical Care, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, 1 Rimini St., Haidari, 12462, Athens, Greece.
Metabolism open
|July 10, 2024
概括
患有败血症的重症患者往往缺乏维生素D. 不幸存者比幸存者具有较低的副甲状腺激素 (PTH) 水平,这表明维生素D,PTH和败血症结局之间的潜在联系.
科学领域:
- 关键护理医学 关键护理医学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 低维他命症D在重症患者中很常见,可能会增加感染,败血症和死亡风险.
- 维生素D状况与败血症严重程度/结果之间的关系需要进一步研究.
研究的目的:
- 检查血清25-氧维生素D (25(OH) D) 和副甲状腺激素 (PTH) 水平之间的关联以及重症患者新发性败血症的严重程度和结果.
主要方法:
- 对50名患有新发性败血症的重症成人和50名匹配的健康对照进行前性研究.
- 血清25 (((OH) D和PTH在患者的败血症发病时和一周后测量.
- 用于维生素D和PTH测定的电化学发光免疫测试.
主要成果:
- 严重性败血症患者在败血症发作时的25(OH) D (7.9 ng/mL) 比对照组 (24.6 ng/mL) 显着较低.
- 80%的败血症患者 (40/50) 缺乏维生素D (<12 ng/mL),包括所有10名未幸存者.
- 与幸存者相比,非幸存者表现出较低的PTH水平.
- 25 (((OH) D与电离正相关,与PTH负相关;与炎症标志物或严重性得分没有相关性.
结论:
- 维生素D缺乏症在患有败血症的重症患者中非常普遍.
- 与幸存者相比,非幸存者观察到较低的PTH水平.
- 需要进一步的大规模研究来澄清维生素D和PTH在败血症发病和结果中的作用.
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