烟草暴露与膀癌复发之间的关联:系统性审查和元分析
Lei Xiang1, Qi-Qi Xie2, Si-Si Xu2
1Department of Rehabilitation Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
World journal of methodology
|July 10, 2024
概括
吸烟显著增加了膀癌复发和进展的风险. 这一元分析证实了烟草暴露是膀癌的主要因素.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 吸烟和膀癌预后之间的关联尚未得到充分证实.
- 了解这种联系对于患者管理和公共卫生倡议至关重要.
研究的目的:
- 研究吸烟与膀癌复发和进展之间的关系.
- 通过元分析来综合现有证据.
主要方法:
- 在PubMed,Web of Science和Cochrane图书馆进行了系统的文献搜索.
- 来自12项相关的英语研究的数据使用随机效应模型进行了聚合.
- 进行了子组和灵敏度分析以探索异质性.
主要成果:
- 吸烟显著增加了膀癌复发率 (OR=1.76) 和进展率 (OR=1.21).
- 与从未吸烟者相比,目前和前吸烟者面临的复发风险更高.
- 非高加索人可能会表现出对膀癌复发的敏感性增加.
结论:
- 暴露于烟草是膀癌复发和进展的重要危险因素.
- 戒烟干预措施对于改善膀癌患者的治疗结果至关重要.
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