EGFR-TKIs - 在NSCLC中诱导心脏毒性:发生率,评估和监测
Yunlong Wang1, Qinggui Qiu1, Xuan Deng1
1Department of Oncology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
Frontiers in oncology
|July 10, 2024
概括
针对非小细胞肺癌 (NSCLC) 的向疗法可能导致严重的心脏毒性. 早期识别和管理心血管副作用对于改善患者的治疗结果和生存率至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 向药物治疗已经彻底改变了高级非小细胞肺癌 (NSCLC) 治疗.
- 针对性疗法的心脏毒性是一个重大问题,影响预后和生存率.
- 心血管疾病是癌症患者死亡的第二大原因.
研究的目的:
- 讨论新型向药物的心脏毒性副作用,特别是表皮生长因子受体抑制剂.
- 总结与这些疗法相关的心血管不良反应的机制.
- 为接受向治疗的高级NSCLC患者提供心脏管理建议.
主要方法:
- 对与针对NSCLC的向治疗相关的心脏毒性副作用的审查.
- 讨论心血管不良事件背后的机制.
- 监测策略的总结,包括心电图,心脏成像和生物标志物.
主要成果:
- 确定了潜在的心脏毒性影响,包括血栓栓塞事件,心力衰竭,心肌病,心律失常和高血压.
- 总结了这些不良心血管反应的机制.
- 提出了临床管理和监测的建议.
结论:
- 对于接受向治疗的晚期NSCLC患者来说,早期发现和治疗心脏毒性至关重要.
- 临床医生必须平衡向治疗的好处与药物诱导心脏毒性的风险.
- 定期监测和风险因素管理对于优化治疗结果和患者存活率至关重要.
更多相关视频
08:03Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
Published on: October 20, 2022
1.8K
09:38Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
Published on: June 26, 2019
7.9K
相关概念视频
02:38Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K