开发和验证胃癌患者的预后免疫炎症指数
Zhi-Chang Ba1,2, Xi-Qing Zhu3,2, Zhi-Guo Li3
1Department of Radiology, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang Province, China.
World journal of gastroenterology
|July 10, 2024
概括
一个新的预后免疫炎症指数 (PII) 有效地预测胃癌患者的结果. 该指数整合了免疫和炎症标记,为手术治疗和临床实践提供了宝贵的见解.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 炎症研究的研究.
背景情况:
- 免疫和炎症显著影响瘤的发展.
- 虽然单个生物标志物存在,但对于胃癌预后的综合标志物研究不足.
研究的目的:
- 评估手术治疗胃癌患者的炎症生物标志物和淋巴细胞的预后和临床重要性.
- 开发和验证一种新的胃癌预后指数.
主要方法:
- 单变性COX回归确定了预后因素.
- 最小绝对收缩和选择经营者-COX (LASSO-COX) 回归形成了预后免疫炎症指数 (PII).
- 用曲线和决策曲线分析下的时间依赖面积来开发和验证名图.
主要成果:
- 中性粒细胞与淋巴细胞的比率,血小板与淋巴细胞的比率以及系统性免疫炎症指数的升高与较差的无进展存活率 (PFS) 和整体存活率 (OS) 相相关.
- 特定的T淋巴细胞水平 (低CD3+,CD3+CD8+,CD4+CD8+,CD3+CD16+CD56+;高CD19+) 与PFS和OS有明显的关联.
- PII得分独立预测了PFS和OS,并与瘤特征相关;基于PII的诺米图证明是有效的.
结论:
- 预后免疫炎症指数 (PII) 显示,它有可能成为接受手术的胃癌患者可靠的预后预测指标.
- PII提供了有关癌症的免疫-炎症反应的见解,表明临床实用性.
更多相关视频
07:32Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
1.3K
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
416
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
01:27Gastritis-I: Introduction and Types
345
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
345