管理免疫检查点抑制剂相关胃炎:见解和策略
Li-Li Yu1,2, Zhi-Lin He1,3, Xin-Lai Qian1,3
1Department of Pathology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
World journal of gastroenterology
|July 10, 2024
概括
免疫检查点抑制剂 (ICI) 有效治疗瘤,但可能导致与免疫相关的不良事件 (irAEs). 胃肠道IRAE,如腹和结肠炎,很常见,可能需要停止ICI治疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 免疫检查点抑制剂 (ICI) 在癌症治疗中至关重要.
- 免疫相关的不良事件 (irAEs) 是已知的ICI的副作用.
- 胃肠道IRAE,包括腹和结肠炎,经常发生.
研究的目的:
- 概述了在接受免疫检查点抑制剂 (ICI) 的患者中胃肠道免疫相关不良事件 (irAEs) 的影响.
- 要突出与ICI治疗相关的胃肠道副作用的临床意义.
主要方法:
- 对ICI诱导的胃肠道毒性临床数据和相关文献的审查.
- 对接受ICI治疗的患者报告的腹和结肠炎病例的分析.
主要成果:
- 胃肠道IRAE是ICI治疗中的一个重要问题.
- 腹和结肠炎等症状可能是严重的.
- 这些不良事件可能导致治疗中断,影响患者的治疗结果.
结论:
- 胃肠道IRAE是免疫检查点抑制剂治疗的常见且潜在的严重并发症.
- 对这些副作用的管理对于维持治疗的连续性和有效性至关重要.
- 进一步研究减轻胃肠道IRAE是有必要的.
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