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在中国武汉的健康儿童中,高灵敏性心脏托罗邦素I的特定参考间隔

Qinzhen Cai¹, Mei Liu², Zhen Xie³

¹Department of Laboratory Medicine, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

Translational pediatrics

|July 10, 2024

概括

这项研究确定了儿童高灵敏性心脏托罗素I (hs-cTnI) 的关键年龄和性别特定的参考间隔. 这些发现有助于诊断儿科心肌损伤和全身性疾病.

科学领域:

临床生物化学临床生物化学
儿童心脏病学儿童心脏病学
诊断生物标志物诊断生物标志物

背景情况:

心脏中位素 (Tn) 对于诊断心肌损伤和评估儿童全身疾病至关重要.
对于儿科人群中高灵敏性心脏素I (hs-cTnI) 存在有限的特定参考间隔 (RIs).
确定儿科hs-cTnI RI对于准确的临床评估至关重要.

研究的目的:

在健康的新生儿,儿童和青少年中建立血清hs-cTnI的初步年龄和性别特定的参考间隔.
为解释中国武汉儿童群体hs-cTnI水平提供基础数据集.

主要方法:

一项横截面研究包括1355名健康参与者,年龄在中国武汉市1天至19岁之间.
使用Mindray自动化化学发光免疫测试分析仪 (CL-6000i) 测量血清hs-cTnI水平.
根据临床和实验室标准研究所 (CLSI) 的指导方针确定参考间隔,定义P50 (中位数) 和P2.5-P97.5 (95%间隔).

主要成果:

总体hs-cTnI P50 (P2.5-P97.5) 为0.41 (0.00,44.31) ng/L,男性 (0.47 ng/L) 比女性 (0.36 ng/L) 更高.
在婴儿 (<1岁) 中,水平高度变化,P50 (P2.5-P97.5) 为22.06 (1.04,154.22) ng/L,随着年龄的增长而下降.
建立了特定于年龄和性别的RI,显示了与发展和青春期相关的独特模式.

结论:

在武汉的健康儿童中,初步的特定年龄和性别的血清hs-cTnI参考间隔已成功确定.
这些RI使用Mindray CL-6000i系统获得,为儿科临床实践提供了关键资源.
这些发现强调了年龄和性别因素在解释儿童hs-cTnI水平方面的重要性.

关键词:

高灵敏性心脏托罗邦素I (hs-cTnI) 的使用孩子们的孩子们的孩子们的孩子们心肌损伤是指心肌损伤.新生儿新生儿的新生儿参考时间间隔 (RIs)

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