氧化释放纳米材料用于心血管应用
Tanveer A Tabish1, Mark J Crabtree1,2, Helen E Townley3,4
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation (BHF) Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.
JACC. Basic to translational science
|July 10, 2024
概括
氧化 (NO) 纳米材料通过精确地将NO输送到功能障碍的部位,提供有针对性的心血管治疗. 这些先进的材料旨在改善对诸如动脉样硬化和高血压等疾病的治疗,并减少副作用.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 心血管医学 心血管医学
背景情况:
- 降低氧化 (NO) 生物可用性对心血管功能障碍至关重要,包括血管扩张,血栓形成和炎症等问题.
- 传统的NO供体缺乏有针对性的输送,需要精确的NO给药以达到安全有效的治疗水平.
- 纳米材料为局部NO产生或在体内释放提供了新的策略.
研究的目的:
- 审查用于心血管治疗的NO释放纳米材料的设计和开发方面的进展.
- 批判性地研究纳米平台在调节细胞代谢和血管度方面的治疗潜力.
- 评估NO释放纳米材料抑制血小板聚合和血管光滑肌肉增殖的能力.
主要方法:
- 对利用聚合物,无机 (二氧化,黄金) 纳米粒子和纳米金属有机框架进行NO输送的近期策略的审查.
- 讨论内生产生NO或储存和释放NO气体的纳米材料.
- 检查血管植入物中的应用,如用于心血管疾病的支架和移植.
主要成果:
- 释放NO的纳米材料显示出针对性治疗动脉样硬化,高血压和缺血-再输液损伤的潜力.
- 纳米平台可以调节细胞代谢,调节血管度,并抑制血小板聚合.
- 这些纳米材料提供了一种有前途的方法,以限制血管光滑肌肉的增殖,并具有潜在的最小毒性影响.
结论:
- 释放NO的纳米材料代表了心血管治疗的重大进步.
- 通过纳米平台的向NO输送有望治疗一系列心血管疾病.
- 对这些纳米技术的进一步研究可能会导致改善患者的治疗结果和新的治疗策略.
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