刚果COVID-19患者的氧化-阿兹胺素,双C和QTc延长:神话还是现实?
Brady Madioko Makanzu1, Jean-Robert Makulo2, Madone Ndona Mandina3
1Department of Cardiology, Kinshasa University Hospital, Kinshasa, DR Congo, Kinshasa University Hospital, Kinshasa 11, Congo. bmaknzu@gmail.com.
与双C相比,COVID-19的氧化 (HCQ) 和亚胺 (AZI) 治疗显示了较低的QTc延长率.这项研究在任何治疗组中都没有发现torsade de pointes (Tsd),这表明HCQ-AZI在特定患者群体中具有潜在的安全性.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 在COVID-19患者中,与氧化 (HCQ) 和亚胺 (AZI) 相关的QTc间隔延长和torsade de pointes (Tsd) 风险是一个已知的问题.
- 在刚果民主共和国,关于这种药物组合和替代治疗的安全性研究有限.
研究的目的:
- 在接受HCQ-AZI治疗的COVID-19患者中,比较QTc延长和Tsd的发生率与新分子,doubase C.对比.
- 在随机临床试验环境中评估HCQ-AZI和doubase C的安全性.
主要方法:
- 一项随机临床试验包括患有轻度至中度COVID-19的患者,接受HCQ-AZI或双基C.
- 随机化后的第14天进行了心电图 (ECG) 评估,将QTc间隔与基线进行了比较.
- 延长的QTc被定义为≥500毫秒或从基线增加≥80毫秒;心脏病患者或混药物被排除在外.
主要成果:
- 这项研究招募了258名患者;1.5%的患者经历了QTc延长 (>500毫秒),1.9%的患者QTc增加 (>80毫秒).
- 年轻的患者,基线病毒载量高的患者和接受HCQ-AZI的患者 (P <0.05) 的QTc延长更为明显.
- 在任何治疗组中都没有报告Td病例.
结论:
- 与双基C相比,在接受HCQ-AZI治疗的患者中,QTc延长发生的频率较低,没有观察到Tsd.
- 没有并发症和同时使用延长QTc的药物可能有助于观察到的安全性.
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