在甲状腺眼睛疾病的环境中对眼睛表面处理的系统审查
Anthony Stephen Wong1, James G Chelnis2,3
1Department of Ophthalmology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, United States.
Frontiers in ophthalmology
|July 10, 2024
概括
甲状腺眼部疾病通常会导致干眼症状,原因是复杂的膜变化. 目前的治疗方法提供了一些缓解,但需要更多的研究,以获得最佳的甲状腺相关干眼管理.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 眼睛表面疾病 眼睛表面疾病
背景情况:
- 甲状腺眼病 (TED) 影响~85%的患者有眼表面症状.
- 在TED的异常催膜组成是复杂的,超越角膜暴露.
- 目前用于甲状腺相关干眼的治疗方法往往缺乏特定的疗效.
研究的目的:
- 系统地审查目前对甲状腺眼病中干眼症状的治疗方法.
- 评估TED患者眼睛表面参数上的各种治疗方法的疗效.
主要方法:
- 通过Medline,Cochrane CENTRAL,PubMed和谷歌学者进行系统的文献搜索.
- 包括评估TED患者干眼治疗的研究,直到2023年10月.
主要成果:
- 七项研究符合纳入标准,检查了局部和非局部治疗.
- 多种模式显示主观和客观的眼表面参数有所改善.
- 有限的研究数量和设计变化阻止了确定最终的最佳实践.
结论:
- 现有的治疗方法为甲状腺相关的干眼提供了症状缓解.
- 对于有效的,以证据为基础的治疗方法有着显著的未满足的需求.
- 进一步的精心设计的研究对于为TED患者开发有针对性的,非侵入性的第一线选择至关重要.
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