在接种呼吸道共性病毒 (RSV) 疫苗后的多肌痛性风湿症
Mohamad El Labban1, Stevan Oluic1, Hussein Guleid1
1Department of Internal Medicine, Mayo Clinic Health System, Mankato, USA.
European journal of case reports in internal medicine
|July 10, 2024
概括
多发性肌痛性风湿 (PMR) 发作可能是由疫苗引发的. 一份病例报告将新型呼吸道同胞性病毒 (RSV) 疫苗与PMR症状联系起来,强调临床医生需要在诊断中考虑疫苗接种史.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 多发性肌痛性风湿症 (PMR) 是一种炎症性疾病,影响靠近关节.
- 遗传和环境因素与PMR有关.
- 以前的疫苗 (流感,COVID-19) 与PMR发病或复发有关.
研究的目的:
- 在接种呼吸道同胞病毒 (RSV) 疫苗后报告新发性多发性肌痛性风湿病例.
- 调查RSV疫苗接种和PMR之间的潜在联系.
主要方法:
- 一个72岁的男性患者的病例报告.
- 在接种RSV疫苗后对症状的临床观察.
- 监测炎症标志物 (例如,C反应蛋白).
- 对普得尼松治疗反应的评估.
主要成果:
- 患者在接种Abrysvo® RSV疫苗后三天出现了肩部疼痛和硬.
- 观察到炎症标志物升高.
- 症状和炎症标志物在普雷尼松治疗后得到改善.
结论:
- 人类蛋白质组与RSV F抗原共享,表明潜在的交叉反应性.
- 这一案例表明RSV疫苗可能是多发性肌痛风湿症的触发因素.
- 临床医生应考虑在出现PMR症状的患者的疫苗接种史.
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