在COVID-19疫苗免疫接种后与皮肤反应相关的危险因素:基于注册表的病例控制研究
Hwei Lin Teh1, Thamron Keowmani2, Min Moon Tang3
1Pharmacy Department, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
The Malaysian journal of medical sciences : MJMS
|July 10, 2024
概括
马来西亚的COVID-19疫苗接种导致皮肤反应增加,特别是在第一剂后的中年女性中. 过敏史显著增加了这些轻微,可控的皮肤反应的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 公共卫生 公共卫生
背景情况:
- 吉隆坡医院观察到COVID-19疫苗接种后皮肤反应增加.
- 在马来西亚启动了一项病例控制研究,以调查这些反应的潜在风险因素.
研究的目的:
- 为了确定与COVID-19免疫接种后皮肤反应相关的风险因素.
- 分析这些疫苗接种后皮肤反应的特征和管理.
主要方法:
- 一项基于注册表的,无匹配的病例控制研究利用了免疫接种后不良事件 (AEFI) 报告.
- 通过逻辑回归分析评估了24个潜在的风险因素.
- 数据通过马来西亚药物不良反应咨询委员会 (MADRAC) AEFI报告表格收集.
主要成果:
- 皮肤反应在中年女性中更为常见,特别是在第一剂疫苗接种后.
- 相关的危险因素包括对海鲜,贝类,疫苗,药物的过敏,以及皮肤病史.
- 反应主要是轻微的,一般性和疹,52%的反应是延迟的.
结论:
- 对疫苗,食品或药物的自我报告过敏增加了COVID-19疫苗接种后皮肤反应的可能性.
- 这些反应通常是轻微的,可控的,并没有阻止第二剂疫苗.
- 和疹是主要的表现,有效地用抗胰岛素药物和皮质类固醇治疗.
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