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Updated: Jun 30, 2026

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基因表达特征因小鼠脊椎间盘受伤而受到干扰

Ken Chen1, Zuozhen Tian, Huan Wang

  • 1From the Departments of Orthopedic Surgery (KC, HW, LQ) and Physical Medicine & Rehabilitation (ZT, YZ), University of Pennsylvania, Philadelphia, Pennsylvania; Department of Orthopedics, University of Maryland School of Medicine, Baltimore, Maryland (ME-I); Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China (KC); Department of Orthopedic Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, P.R. China (HW); and Section of Rehabilitation Medicine, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania (YZ).

American journal of physical medicine & rehabilitation
|July 10, 2024
PubMed
概括

这项研究使用整个转录组方法确定了参与小鼠椎间盘损伤的新型基因和途径. 这些发现可能会导致新的生物标志物和治疗背痛的治疗点.

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The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...