相关实验视频
Updated: Jun 21, 2025

Modeling Chemotherapy Resistant Leukemia In Vitro
Published on: February 9, 2016
治疗儿童急性白血病后的晚期不良影响
Jelena Roganovic1, Riccardo Haupt2, Edit Bárdi3
1Department of Pediatric Hematology and Oncology, Children's Hospital Zagreb, Zagreb, Croatia; Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka, Croatia.
儿童白血病幸存者面临重大长期健康问题,包括慢性疾病和增加的死亡率. 意识和结构化的监测对于管理这些晚期不良影响至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 幸存者研究研究 幸存者研究
背景情况:
- 当代治疗可以治愈超过90%的急性淋巴细胞白血病 (ALL) 和60%的急性髓性白血病 (AML) 病例.
- 儿童白血病幸存者的很大一部分在诊断后几年就会发展出慢性健康状况,影响生活质量和生存率.
- 这些晚期影响可能会危及生命,导致过早死亡.
研究的目的:
- 提高医疗保健专业人员和政策制定者对儿童白血病幸存者的晚期不良影响的认识.
- 审查这些晚期影响的频率,原因,临床特征和自然史.
- 讨论幸存者护理的当前进展,包括监视和护理计划.
主要方法:
- 关于儿童白血病幸存者的大型队列研究的全面审查.
- 对晚期不良影响的数据分析,包括随后的瘤,代谢,内分泌,骨,神经,心脏和心理社会问题.
- 突出血造干细胞移植幸存者的晚期影响.
主要成果:
- 儿童白血病幸存者经历了广泛的晚期不良影响,如随后的恶性瘤,代谢毒性,生育能力受损,内分泌病变,骨毒性,神经毒性,心脏毒性和心理社会问题.
- 这些影响可能导致加快衰老和增加过早死亡率.
- 晚期影响在血造干细胞移植的幸存者中尤为明显.
结论:
- 提高对晚期影响的严重程度和患病率的认识对于家长,患者,医疗保健专业人员和决策者来说至关重要.
- 结构化的长期监测建议对于标准化后续护理至关重要.
- 由于未知长期结果的新疗法,需要持续保持警.
更多相关视频
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
10:49Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
相关概念视频
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Biological Effects of Radiation
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Skeletal Muscle Relaxants: Adverse Effects
Unlike...