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Updated: Jun 21, 2025

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
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评估从重新加权的基于流量的概率的生成模型中获得的自由能量差异的准确性和效率

Edgar Olehnovics1, Yifei Michelle Liu2, Nada Mehio3

  • 1Thomas Young Centre and Department of Chemical Engineering, University College London, London WC1E 7JE, U.K.

Journal of chemical theory and computation
|July 10, 2024
PubMed
概括

有针对性的自由能量扰动 (TFEP) 使用机器学习创建可逆地图以更快地计算自由能量. 贝内特验收比率 (BAR) 和多州贝内特验收比率 (MBAR) 方法证明数据效率高且可用于重权这些地图.

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