损伤大脑的左右侧特定的神经内分泌信号:一个组织原则
Hiroyuki Watanabe1,2, Yaromir Kobikov3, Olga Nosova1
1Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, SE-751 24, Sweden.
Function (Oxford, England)
|July 10, 2024
概括
一个新的拓神经内分泌系统 (T-NES) 有左侧和右侧,以不同的方式调解脑损伤效应. 这些不同的途径涉及独特的神经机制和分子网络,挑战了以前的神经学教条.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 脑损伤后的神经缺陷传统上归因于交叉的下降神经通道.
- 最近发现了一种新型的拓神经内分泌系统 (T-NES),通过幽默路径运作,以调节单边脑损伤的特定副作用.
研究的目的:
- 调查T-NES是否包括不同的左侧和右侧对应器.
- 为了确定这些对应物是否在神经和分子机制上有所不同.
主要方法:
- 实验是在切断胸部脊髓的老鼠身上进行的.
- 使用阿片类药物对抗剂来阻止荷尔蒙信号传递.
- 进行了脊髓分离和椎脊髓切割.
- 分析了基因与基因的共同表达模式.
主要成果:
- 在T-NES中,左侧和右侧的荷尔蒙信号受阿片类药物抗剂的不同影响.
- 左侧和右侧的神经激素通路以不同的方式准 afferent 脊柱机制.
- 同情神经系统被排除为信号通路.
- 确定了独特的左侧和右侧特异性基因共同表达网络,通过下丘脑和腰椎脊髓进行协调.
结论:
- T-NES是双部分的,有不同的左和右组件.
- 这些组成部分通过不同的神经机制导致相反的神经缺陷.
- T-NES可能有助于在遥远的神经区域中对分子和神经过程的双侧调节.
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