咖啡消费对三个主要骨疾病的影响:孟德尔的随机化试验
Xiang Zhang1,2,3, Jin Xu4,5,6,7,8,9
1Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Journal of bone and mineral metabolism
|July 10, 2024
概括
这项研究发现,增加咖啡消费 (CC) 与膝关节骨关节炎 (KOA) 的更高风险有因果关系. 减少咖啡摄入可能有利于骨健康,这表明这种常见的骨疾病的潜在预防策略.
科学领域:
- 遗传学和流行病学
- 骨和关节疾病 骨和关节疾病
背景情况:
- 关于咖啡消费 (CC) 和骨疾病 (BD) 的观察性研究,如骨关节炎 (OA),骨质疏松性骨折 (OF) 和类风湿性关节炎 (RA),产生了有争议的结果.
- 建立CC和BD之间的因果关系对于公共卫生建议至关重要.
研究的目的:
- 调查咖啡消费与主要骨疾病,特别是骨质疏松性骨折 (OF),类风湿性关节炎 (RA) 和骨关节炎 (OA) 之间的因果关系.
- 利用门德尔的随机化 (MR) 来克服观察性研究的局限性并推断因果关系.
主要方法:
- 孟德尔随机化 (MR) 分析用于评估遗传预测咖啡消费对OF,RA和OA的因果关系.
- 反变量加权 (IVW) 是主要方法,加权中位数 (WM),MR-Egger,MR-PRESSO和多变量MR (MVMR) 用于灵敏度分析.
- 对因果单核酸多态 (SNP) 的功能分析涉及基因本体学 (GO) 和KEGG通路丰富.
主要成果:
- 最初的MR分析表明,CC可能会增加OF,RA和关节骨关节炎 (HOA) 的风险,但这些发现在敏感性测试中缺乏稳定性.
- 在增加咖啡消费和膝关节骨关节炎 (KOA) 风险之间发现了显著的积极因果关系 (OR:2.094,P <1.41x10−7).
- 这种与KOA的关联在所有MR灵敏度分析中保持一致,没有证据表明横向质.
结论:
- 增加咖啡消费因果关系与患膝关节关节炎 (KOA) 的风险更高.
- 遗传证据支持,减少咖啡消费可能有利于保持骨健康,并可能预防KOA.
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