COVID-19相关的小脑动症:一个病例系列
Mange Liu1, Siyuan Fan1, Chang Geng1
1Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Cerebellum (London, England)
|July 10, 2024
概括
罕见的COVID-19相关的小脑缩症是一种罕见的疾病,可以与脑病变一起出现. 感染后的早期发病性动与年轻的年龄,严重的症状和较差的结局有关,短暂的MRI发现.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 神经免疫学 神经免疫学
背景情况:
- 与COVID-19相关的小脑动症很少被报告,对其临床谱的理解有限.
- 在SARS-CoV-2感染后的小脑缩需要进一步调查以描述其特征和预后.
研究的目的:
- 描述COVID-19相关大脑动症患者的临床特征,神经成像发现和免疫学概况.
- 为了比较早期发病 (COVID-19的5天内) 和晚期发病的小脑动症患者之间的结果.
主要方法:
- 11名被诊断患有COVID-19相关的大脑小动症的患者的回顾性病例系列.
- 临床数据收集包括演示,神经成像 (脑磁共振) 和抗小脑抗体测试.
- 基于COVID-19发病和无氧表现之间的间隔结果的比较.
主要成果:
- 确定了11名患者 (4名男性,平均年龄38岁);5人呈现脑病变.
- 大脑MRI显示,在6名患者中发现了不起眼的发现,在5名患者中发现了暂时的双边小脑病变;后来注意到大脑缩.
- 早期发病的动力衰退 (间隔<5天) 与年轻的年龄,脑病变的可能性更高,症状更严重和预后更差有关.
结论:
- 与COVID-19相关的小脑衰竭可以表现为脑病变,并在MRI上显示短暂的小脑病变.
- 在COVID-19后的早期发病性动症表明疾病的进展更为严重,结果不那么有利.
- 所有患者都接受了免疫疗法,结果在9例病例中改善.
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