在艾滋病毒感染的病毒抑制女性中,托芬-金林路径激活和认知
Eran Frank Shorer1, Raha M Dastgheyb1, Audrey L French2
1Department of Neurology, Johns Hopkins Hospital, Baltimore, MD.
Journal of acquired immune deficiency syndromes (1999)
|July 10, 2024
概括
印列氨胺2,3-二氧化酶 (IDO) 激活,以金氨酸与氨酸 (K:T) 的比率表示,与艾滋病毒感染妇女的精细运动功能受损有关,即使在病毒抑制的情况下也是如此. 这种关联无论系统性炎症如何,都会持续存在.
科学领域:
- 神经免疫学 神经免疫学
- 艾滋病毒 医学 艾滋病毒 医学
- 代谢途径 代谢途径
背景情况:
- 持续的免疫和认知功能障碍发生在艾滋病病毒抑制妇女 (VS-WWH).
- 炎症和HIV蛋白质可以激活胺二氧化酶 (IDO),改变托代谢,并可能导致神经毒性.
研究的目的:
- 研究VS-WWH中IDO激活 (通过K:T比率测量) 和认知功能之间的关系.
- 为了比较VS-WWH和人口统计学上相似的没有艾滋病毒的妇女 (WWoH) 之间的IDO激活和认知功能.
主要方法:
- 对99个VS-WWH和102个WWoH进行了神经心理测试.
- 测量了托-金林代谢物和炎症标志物的血水平.
- 使用金氨酸与托芬 (K:T) 的比率来评估IDO激活.
主要成果:
- 与WWoH相比,VS-WWH表现出较高的K:T比率和升高的sCD14水平.
- 在VS-WWH中,较高的sCD163水平与较高的K:T比和较差的精细运动功能相关.
- 在调整炎症标志物后,在VS-WWH中,IDO激活仍然与精细运动功能受损有显著的关联.
结论:
- IDO激活与VS-WWH中精细运动控制的恶化有关,独立于测量的全身炎症.
- 需要进一步的研究来阐明生物机制,将IDO激活与这种人群中的精细运动功能缺陷联系起来.
更多相关视频
10:12Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity
Published on: June 14, 2024
1.9K
10:38Simultaneous Quantification of Selected Kynurenines Analyzed by Liquid Chromatography-Mass Spectrometry in Medium Collected from Cancer Cell Cultures
Published on: May 9, 2020
3.4K
相关概念视频
01:23Antidepressant Drugs: MAOIs and Other Agents
215
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
215
01:29Pulmonary Tuberculosis I
231
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
231