在NHANES中使用大麻和血红蛋白度2009-2018:对亚临床低氧症的影响
Cancan Zhang1, Hui Zhang2, Bo Zhang3,4
1Department of Medicine and.
Annals of the American Thoracic Society
|July 10, 2024
概括
目前使用大麻与美国成年人的血红蛋白水平更高有关,类似于吸烟. 这一发现表明吸食大麻可能导致低氧化,需要进一步研究.
科学领域:
- 公共卫生 公共卫生
- 毒理学 毒理学 毒理学
- 血液学 血液学 血液学
背景情况:
- 在美国,大麻的使用量正在增加,但其对健康的影响,特别是与吸烟相比,仍然不清楚.
- 之前对大麻和血红蛋白的研究由于样本大小小或人口不代表性而产生了不一致的结果.
- 血红蛋白水平可能表明亚临床低氧化症或一氧化碳暴露.
研究的目的:
- 为了调查大麻使用与血红蛋白度之间的关联,在美国成年人的一个大型,全国代表性样本中.
- 为了比较大麻使用对血红蛋白的影响与吸烟和使用二二类药物的影响.
- 为了解大麻消费对生理影响提供见解.
主要方法:
- 这项横截面研究利用了来自国家健康和营养检查调查 (NHANES) (2009-2018) 的16038名成年人 (18-59岁) 的数据.
- 多变量分析根据人口统计,教育,住房和吸烟情况进行调整,并纳入复杂的调查权重.
- 检查了目前/以前使用大麻,吸烟和使用二类药物与测量血红蛋白度之间的关联.
主要成果:
- 当前使用大麻与更高的血红蛋白度 (0.111 g/dl增加;P=0.01) 有关.
- 以前的大麻使用显示出更高血红蛋白的趋势,尽管在统计学上并不显著.
- 吸烟也与更高的血红蛋白相关,而使用二二类药物则没有.
结论:
- 目前在美国成年人中使用大麻与血红蛋白水平升高有关,这与吸烟的研究结果相似.
- 这些结果表明,大麻吸烟可能会诱导亚临床低氧化,刺激血红蛋白的产生.
- 需要进一步的研究来证实这些观察结果,因为医疗和娱乐大麻使用的增加.
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