伊朗人口中二手烟暴露和肺癌风险:一个多中心病例控制研究
Fereshte Lotfi1,2, Hamideh Rashidian1, Maryam Hadji1,3
1Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
PloS one
|July 10, 2024
概括
暴露于二手烟雾 (SHTS) 显著增加肺癌风险,特别是在从未吸烟的人群中. 即使是短暂的每日暴露也会增加患肺癌的几率,这凸显了需要更严格的SHS法规的必要性.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 公共卫生政策 公共卫生政策
背景情况:
- 暴露于二手烟 (SHS) 仍然是一个重大的公共卫生问题,特别是在烟草控制挑战持续存在的地区.
- 尽管有国际框架,但从各种烟草产品中有效监管SHS需要进一步调查.
- 了解从水管,管道,chopogh和片中产生的SHS相关的特定风险对于有针对性的干预至关重要.
研究的目的:
- 研究各种烟草产品的二手烟 (SHS) 暴露和片使用与肺癌风险之间的关联.
- 在一般人群和从未吸烟者中量化SHS暴露导致的肺癌风险增加.
- 为伊朗的公共卫生战略和烟草控制政策提供信息.
主要方法:
- 一项多中心病例控制研究,涉及627例肺癌病例和3477例对照.
- 从烟草和片中暴露于SHS的数据通过问卷收集.
- 混合模型后勤回归被用来计算几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 对二手烟草烟雾 (SHTS) 的总体暴露与肺癌风险增加1.35倍有关 (OR=1.35,95% CI:1.08-1.71).
- 暴露于SHTS的从未吸烟者面临的肺癌风险增加了1.69倍 (OR=1.69,95% CI:1.13-2.52).
- 每天暴露在SHTS中2-3小时 (OR=2.27) 或超过3小时 (OR=2.29) 显著增加肺癌风险 (P趋势<0.01). 对于二手片烟 (SHOS) 没有发现任何关联.
结论:
- 暴露于二手烟雾 (SHTS) 是普通人群和从未吸烟者中肺癌的重要危险因素.
- 调查结果强调,迫切需要改进SHS法规和开展公众宣传活动.
- 需要进一步的研究,以阐明与水管,管道,chopogh和片SHS相关的肺癌风险.
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