食纤维诱导与肠道微生物群相关的脂肪偏好
Yi Jia Liow1,2, Itsuka Kamimura2, Masahiro Umezaki1,2
1Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Bunkyo City, Tokyo, Japan.
PloS one
|July 10, 2024
概括
食纤维摄入量,特别是胰岛素,可以影响小鼠未来的食物偏好. 食胰岛素的小鼠更喜欢高脂肪饮食而不是高糖饮食,这与肠道微生物群的变化有关.
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 行为科学 行为科学
背景情况:
- 饮食行为对人类健康至关重要.
- 之前的饮食组成对未来饮食行为的影响仍然在很大程度上未被探索.
- 了解饮食偏好对食物偏好的饮食条件对于公共健康至关重要.
研究的目的:
- 为了研究食纤维 (胰岛素) 如何影响随后的高脂肪饮食与高糖饮食的食物偏好.
- 探索食纤维干预,食物偏好和肠道微生物群组成之间的相关性.
- 为了识别与脂肪偏好相关的特定肠道微生物.
主要方法:
- 在雄性C57BL/6NJcl小鼠中使用对照或胰岛素饮食进行为期2周的饮食干预.
- 一个为期3天的饮食行为测试,允许在高脂肪和高糖饮食之间进行自我选择.
- 分析便样本以确定肠道微生物群的组成.
主要成果:
- 食胰岛素的小鼠更喜欢高脂肪饮食而不是高糖饮食.
- 在接受胰岛素调节的小鼠和对照小鼠之间观察到不同的肠道微生物群概况.
- 特定的肠道细菌 (Oscillospiraceae sp., Bacteroides acidifaciens,Clostridiales sp.) 已经成为一种常见的疾病. 与脂肪偏好有积极的相关性.
结论:
- 饮食干预可以诱导新的食物偏好.
- 肠道微生物群的组成与饮食诱导的食物偏好变化有关.
- 需要进一步的研究来证实肠道微生物群在宿主食物偏好中的因果作用.
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