一个开放的,随机的受控试验,以评估在患有败血症的重症患者的食饮食
Tim Rahmel1, David Effinger2,3, Thilo Bracht1
1Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Knappschaftskrankenhaus Bochum, 44892 Bochum, Germany.
Science translational medicine
|July 10, 2024
概括
性饮食 (KD) 可以在败血症患者中安全诱导症,减少胰岛素需求和免疫失调. 这种方法可能会改善临床结果,并在更大的试验中进行进一步的研究.
科学领域:
- 关键护理医学 关键护理医学
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 败血症会导致代谢和免疫功能障碍,标准高碳水化合物营养可能会使其恶化.
- 性饮食 (KD) 是一种潜在的替代方案,但临床证据很少.
研究的目的:
- 评估在重症败血症患者中使用性饮食 (KD) 诱导稳定症的可行性和安全性.
- 探索KD对败血症临床和免疫学标志物的影响.
主要方法:
- 一个单中心,开放标签,随机对照试验,涉及40名患有败血症的重症成人.
- 患者被随机分配到基因饮食或标准高碳水化合物饮食中.
- 结果包括对症的评估,安全性,临床参数和免疫细胞分析.
主要成果:
- 在所有KD患者中都实现了稳定的症,β-基酸盐水平显著升高.
- 没有观察到KD的重大不良事件或有害的代谢副作用.
- 癌症患者的胰岛素依赖性降低,无通风,无血管压缩剂,无透析和无ICU的日数改善,免疫调节障碍降低.
结论:
- 饮食是安全和有效的诱导稳定的症在严重疾病的败血症患者.
- 凯迪可以减轻免疫失调并改善败血症的临床结果.
- 需要进行更大规模的试验来证实KD在与败血症相关的器官功能障碍中的治疗益处.
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