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Updated: Jun 21, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

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人类化学因子受体CCR8的冷电磁结构和生物化学分析

Qi Peng1,2, Haihai Jiang1,2, Xinyu Cheng1,2

  • 1The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.

Biochemistry
|July 10, 2024
PubMed
概括

研究人员确定了在活性状态下C-C动机化学因子受体8 (CCR8) 的冷电子显微镜结构. 这种对LMD-009等激动剂的CCR8激活的结构性洞察力有助于开发针对癌症和自身免疫性疾病的向疗法.

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Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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