预测轻度认知障碍或轻度痴呆症的氨基酸阳性患者的认知衰退
Pieter J van der Veere1, Jeroen Hoogland1, Leonie N C Visser1
1From the Alzheimer Center and Department of Neurology (P.J.v.d.V., L.N.C.V., A.C.V.H., H.F.R.-M., S.A.M.S., V.V., W.M.V.D.F.), and Department of Epidemiology and Biostatistics (P.J.v.d.V., J.H., L.N.C.V., J.B., W.M.V.D.F.), Amsterdam Neuroscience, VU University Medical Center; Amsterdam Neuroscience (P.J.v.d.V., L.N.C.V., A.C.V.H., H.F.R.-M., V.V., C.E.T., E.G., W.M.V.D.F.), Neurodegeneration the Netherlands; Division of Clinical Geriatrics (L.N.C.V.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Medical Psychology (L.N.C.V.), Amsterdam UMC Location AMC, University of Amsterdam; Amsterdam Public Health (L.N.C.V.), Quality of Care, Personalized Medicine; Internal Medicine (H.F.R.-M.), Geriatric Medicine Section, Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC Location VUmc; Department of Clinical, Neuro and Developmental Psychology (S.A.M.S.), Faculty of Movement and Behavioral Sciences, VU University; Department of Radiology & Nuclear Medicine (F.B., E.G.), Amsterdam UMC, Vrije Universiteit, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing (F.B.), University College London, United Kingdom; and Neurochemistry Laboratory and Biobank (C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, the Netherlands.
研究人员开发了阿尔茨海默病 (AD) 轻度认知障碍 (MCI) 或轻度痴呆症患者认知衰退的预测模型. 这些模型预测认知轨迹,帮助个性化治疗讨论.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 阿尔茨海默病 (AD) 呈现出可变的认知衰退率.
- 改变疾病的治疗方法需要准确预测认知轨迹.
- 预测认知衰退对于管理AD进展至关重要.
研究的目的:
- 开发临床适用的认知衰退预测模型.
- 预测轻度认知障碍 (MCI) 或轻度痴呆症的粉素阳性个体的认知轨迹.
- 为了帮助个性化的治疗计划为AD.
主要方法:
- 利用从阿姆斯特丹痴呆症队列的纵向迷你精神状态检查 (MMSE) 数据的线性混合建模.
- 包括患有MCI或轻度痴呆症的粉素阳性参与者.
- 纳入了基线预测因素 (年龄,性别,MMSE,APOE ε4,CSF生物标志物,MRI体积) 和立方时间曲线.
主要成果:
- 开发了MCI和轻度痴呆症的单独模型,随着时间的推移预测MMSE.
- 确定了影响认知轨迹的关键预测因素,包括年龄,性别,CSF Aβ1-42,pTau,APOE ε4和基线MMSE.
- 通过内部交叉验证实现了MCI的0.15和轻度痴呆的0.26的解释变异 (R2).
结论:
- 成功构建模型来预测MCI和轻度痴呆症的认知衰退 (MMSE).
- 这些模型提供了对个人的认知轨迹和治疗效果的见解.
- 促进有关预后和治疗干预措施的知情患者讨论.
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