脑小脑中风后年轻成年人的认知障碍:患病率和纵向过程
Stacha F I Reumers1, Mijntje M I Schellekens1, Selma Lugtmeijer2
1Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, Department of Neurology, 6525 GA, Nijmegen, the Netherlands.
概括
在年轻人中小脑中风后,认知障碍很常见,特别影响视觉空间和执行功能. 许多患者随着时间的推移而经历认知衰退,通常伴随着疲劳和主观投诉.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 认知心理学 认知心理学
背景情况:
- 年轻患者的大脑中风可能导致认知障碍,但这些缺陷的具体性质和进展尚不清楚.
- 在年轻人中小脑中风后对认知缺陷的现有研究是有限的.
- 这项研究调查了脑小脑中风的年轻幸存者的大量队列中认知障碍的患病率和发展轨迹.
研究的目的:
- 确定脑小脑中风后年轻患者认知障碍的患病率和特征.
- 分析这个患者群体认知缺陷的纵向过程.
- 探索损伤位置,主观认知投诉和疲劳之间的相关性.
主要方法:
- 60名患有小脑中风的年轻成年人 (18-49岁) 接受了全面的神经心理评估.
- 评估是在中风后的亚急性 (<9个月) 和慢性 (≥9个月) 阶段进行的.
- 使用标准化得分,可靠变化指数,减法分析和相关性分析来评估表现,变化,损伤关联和主观症状.
主要成果:
- 认知障碍是普遍存在的,在亚急性阶段影响了60.3%,在慢性阶段影响了51.2%.
- 视觉空间技能和执行功能是最常见的受损领域 (42.5-54.6%).
- 观察到一个异质的过程,其中17.9%的情况有所改善,41.0%的情况有所下降;主观认知投诉和疲劳是常见的和相关的.
结论:
- 认知障碍,特别是视觉空间和执行功能,在年轻人中小脑中风后很常见,与小脑认知情感综合征一致.
- 认知过程是可变的,很大一部分经历下降,主观的抱怨和疲劳是普遍存在的.
- 虽然没有发现特定的损伤-缺陷相关性,但研究结果表明,临床医生应该查并与患者讨论潜在的认知后续.
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