异原子化的单原子纳米酶具有细菌感染伤口治疗的差异性酶状活性
Juyang Zhang1, Baohong Sun2, Shaoze Shi1
1National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
Journal of colloid and interface science
|July 10, 2024
概括
异原子合的单原子纳米酶 (SANZs) 通过改善治疗细菌感染的催化活性来增强化学动力疗法 (CDT). 在SANZ中使用硫可以优化芬顿式反应,从而增强抗菌效果.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 单原子纳米酶 (SANZs) 由于类似酶的活性和特异性,显示出化学动力学疗法 (CDT) 的前景.
- 目前的SANZ在吸附芬顿式反应中间体方面存在局限性,这阻碍了它们的催化效率和CDT有效性.
- 在SANZ中优化金属中心的电子结构对于增强催化活性至关重要.
研究的目的:
- 调查对单原子纳米酶 (Co-SANZs) 对增强CDT的催化性质的原子兴奋剂的影响.
- 为了提高Co-SANZs对黄金葡萄球菌感染的抗菌疗效.
- 探索异质原子诱导的电荷转移与SANZ中的金属中心的催化活性之间的关系.
主要方法:
- 合成和表征杂原子合的Co-SANZs.
- 密度函数理论 (DFT) 计算以调查电荷转移效应和反应机制.
- 在体外抗菌试验和体内伤口愈合研究中,使用聚烯利胺修饰的Co-SANZs.
主要成果:
- 与相比,用硫添加的Co-SANZs表现出更高的过氧化酶类活性.
- DFT的计算证实,硫注射更有效地调节了电子发行,降低了基生成的能量水平.
- 在体外和体外的研究表明,具有显著的抗菌疗效和改善的伤口愈合与硫合的Co-SANZs.
结论:
- 异原子兴奋剂,特别是用硫,可以显著增强CDT的Co-SANZs的催化活性.
- 硫兴奋剂诱导的内在电荷转移效应是优化芬顿类反应和提高抗菌性能的关键.
- 这项研究为设计用于有效化学动力学治疗应用的先进纳米酶提供了新的策略.
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